5-Bromo-oxoisoaporphine platinum(II) complexes exhibit tumor cell cytotoxcicity via inhibition of telomerase activity and disruption of c-myc G-quadruplex DNA and mitochondrial functions.
作者： Zu-Zhuang Wei , Qi-Pin Qin , Ting Meng , Cai-Xing Deng , Hong Liang
DOI: 10.1016/J.EJMECH.2017.12.092
关键词: DNA 、 Molecular biology 、 Tumor cells 、 Platinum 、 Apoptosis 、 Cell culture 、 Telomerase 、 Chemistry 、 Cytochrome c 、 G-quadruplex
摘要: … that of the mono- and bi-metallic polypyridyl Cu II , Pt II , Zn II metal complexes [42] and three Pt(II) dinuclear square complexes (self-assembled Pt 2 L 2 boxes) [34,43], which mainly …
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