Synthesis of tridentate 2,6-bis(imino)pyridyl ruthenium(II) complexes with N-heterocyclic carbene ligands: activation of imidazolium salts.
作者： Hyojong Yoo , Donald H. Berry
DOI: 10.1021/IC501248C
关键词: Medicinal chemistry 、 Oxidative addition 、 Proton NMR 、 Organic chemistry 、 Ruthenium 、 Halide 、 Ligand 、 Hydride ligands 、 Carbene 、 Chemistry
摘要: Low-valent Ru(0) complexes, [η2-N3]Ru(η6-Ar) (1) or {[N3]Ru}2(μ-N2) (2), where Ar = C6H6 C6H5Me, and [N3] 2,6-(2,4,6-(CH3)3C6H2N═CCH3)2C5H3N, activate C–H bonds in imidazolium salts to produce bis(imino)pyridyl ruthenium–(imidazolidin-2-ylidene) [N3]Ru(H)(X)(NHC) (4) (X halides tosylate). Formation of 4 is most likely proceed via oxidative addition, followed by anion coordination, which expected be a useful pathway synthesizing new complexes with both N-heterocyclic carbene (NHC) hydride ligands. A zwitterionic ruthenium complex an ylidic ligand, ruthenium–(2-methyleneimidazoline) complex, 7, was also successfully isolated fully characterized. The 1H NMR spectra the solid-state structure confirm that 7 transition-metal NHC ligands, formed through activation salts.
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