Bone mineral contents and plasma osteocalcin concentrations of Gambian children 12 and 24 mo after the withdrawal of a calcium supplement.

摘要: BACKGROUND: Our randomized, placebo-controlled supplementation study of 160 rural Gambian children aged 8.3-11.9 y showed that an increase in calcium intake 714 mg/d for 12 mo resulted a 5% forearm bone mineral acquisition and 22% decrease plasma osteocalcin concentration, formation marker, but had no effect on height or dimensions. OBJECTIVE: We investigated whether these results were sustained after supplement withdrawal. DESIGN: All participants followed up (FU1) 24 (FU2) ended. Bone content (BMC), density (BMD), BMC adjusted width, body weight, (size-adjusted BMC) measured at the midshaft distal radius. Plasma concentration was FU1. RESULTS: At follow-up, group greater status than did placebo radius (mean difference +/- SE), FU1: (4.7 1.6%; P = 0.004), BMD (5.1 1.1%;