Hypermutation of HIV-1 DNA in the absence of the Vif protein.

作者: D. Lecossier

DOI: 10.1126/SCIENCE.1083338

关键词: Viral infectivity factorBiologyCUL5Cytidine deaminationAPOBEC3ACytidine deaminase activityAPOBEC3GVirologySomatic hypermutationAPOBEC-3G Deaminase

摘要: … in the absence of Vif, virions produced in nonpermissive H9 cells contain an activity that results in the introduction of C→ U changes into the minus-strand of … with editing of the minus-…

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