Plasmin-mediated fibrinolysis by variant recombinant tissue plasminogen activators

作者： S. Urano , A. R. Metzger , F. J. Castellino

关键词: Biochemistry 、 Biological activity 、 Fibrinolysis 、 Recombinant DNA 、 Urokinase 、 Fibrinolysin 、 Activator (genetics) 、 Chemistry 、 Tissue plasminogen activator 、 Plasmin

摘要: … In conclusion, use of domain-variant and point-mutated rTPA and plasminogen derivatives in an overall clot lysis system has revealed important aspects of the mechanism of activation …