Von Willebrand Factor, Type 2 Diabetes Mellitus, and Risk of Cardiovascular Disease The Framingham Offspring Study
作者： David S. Frankel , James B. Meigs , Joseph M. Massaro , Peter W.F. Wilson , Christopher J. O'Donnell
DOI: 10.1161/CIRCULATIONAHA.108.792986
关键词: Medicine 、 Insulin 、 Framingham Risk Score 、 Diabetes mellitus 、 Type 2 Diabetes Mellitus 、 Type 2 diabetes 、 Internal medicine 、 Endocrinology 、 Von Willebrand factor 、 Body mass index 、 Insulin resistance
摘要: Background—Von Willebrand factor (vWF) is inconsistently associated with cardiovascular disease (CVD). This might be explained by associations of vWF type 2 diabetes mellitus and insulin resistance. Methods Results—We tested whether predicted incident CVD in 3799 Framingham Offspring Study participants, particular, among those or During 11 years follow-up, 351 participants developed CVD. In proportional hazards models (with adjustment for age, sex, blood pressure, smoking, body mass index, total high-density lipoprotein cholesterol, treatment aspirin, insulin, antihypertensives, lipid-lowering medications) the lowest quartile distribution as referent, hazard ratio (HR) was 0.94 second quartile, 0.98 third, 1.32 highest (P=0.04 trend). Additional resistance (homeostasis model) partially attenuated associ...
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