Angiotensin converting enzyme inhibition prevents development of muscle and nerve dysfunction and stimulates angiogenesis in streptozotocin-diabetic rats.

摘要: The effects of the angiotensin converting enzyme inhibitor lisinopril on slow and fast twitch muscle contractile properties, nerve conduction hypoxic resistance, capillary density were examined in streptozotocin-diabetic rats. Prolongation soleus contraction relaxation partially prevented by treatment (p<0.01). A 22% deficit extensor digitorum longus tetanic tension production was also ameliorated Sciatic motor sensory velocity, 25% 12% reduced diabetes respectively, 75% normalized There a 47% increase resistance to block with Lisinopril resulted normal resistance. Capillarisation little affected diabetes; however, there 17% sciatic nerve, 40% For soleus, smaller treatment-induced led an elevated capillary/muscle fibre ratio These results suggest that promoted angiogenesis. It concluded beneficial effect preventive is likely depend upon reduction peripheral vascular improvement tissue blood flow, which implicates relative hypoxia as important factor development myopathy neuropathy experimental diabetes.