Chitosan/OA nanoparticle as delivery system for celecoxib: Parameters affecting the particle size, encapsulation, and release
作者： Paula A Méndez , Gloria M Vásquez , Carmiña Gartner , Betty L López , None
DOI: 10.1002/APP.44472
关键词: Chitosan 、 Solvent 、 Nuclear chemistry 、 Polymer chemistry 、 Oleic acid 、 Polymer 、 Zeta potential 、 Nanoparticle 、 Antibacterial activity 、 Particle size 、 Materials science
摘要: Self-assembled nanoparticles prepared from amphiphilic chitosan/oleic acid (Ch/OA) have shown antibacterial activity and potential application as a carrier for hydrophobic anticancer drugs. In this study, low molecular weight chitosan was modified with oleic obtaining degree of substitution (DS) 12%. The critical aggregation concentration (CAC) the Ch/OA polymer obtained (0.025 mg mL−1) is lower in comparison some systems chitosan-fatty acids. self-assembled nanoparticle size optimized by changing concentration, solvent, method, time homogenization to obtain particles sizes around 300 nm positive zeta potential. drug loading about 7 μg mL−1 encapsulation efficiency 75.8 ± 3.6% Celecoxib affected concentration. vitro release behavior performed (PBS, pH 7.4) MES buffer (pH 6) indicated pH-dependent behavior. show stability during 4 weeks after drug. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44472.
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