Physical phenotype of blood cells is altered in COVID-19.

摘要: Clinical syndrome coronavirus disease 2019 (COVID-19) induced by severe acute respiratory 2 (SARS-CoV-2) is characterized rapid spreading and high mortality worldwide. While the pathology not yet fully understood, hyper-inflammatory response coagulation disorders leading to congestions of microvessels are considered be key drivers still increasing death toll. Until now, physical changes blood cells have been play a role in COVID-19 related vascular occlusion organ damage. Here we report an evaluation multiple parameters including mechanical features five frequent cell types, namely erythrocytes, lymphocytes, monocytes, neutrophils, eosinophils. More than 4 million 17 patients at different levels severity, 24 volunteers free from infectious or inflammatory diseases, 14 recovered were analyzed. We found significant lymphocyte stiffness, monocyte size, neutrophil size deformability, heterogeneity erythrocyte deformation size. some these normal values after hospitalization, others persisted for months hospital discharge, evidencing long-term imprint on body.