Risk Factors for Mortality in Dengue Shock Syndrome (DSS)

摘要: Background: Dengue shock syndrome (DSS) is the most severe form of dengue hemorrhagic fever (DHF) and has a high mortality. There are two major pathological changes in DHF determining severity disease, plasma leakage bleeding. Cytokines released during immune response to virus have been thought be mediators process. Methods: The study involved 50 children with DSS, whom 13 (26%) died. We investigated which clinical signs laboratory findings related Results: found that gastrointestinal bleeding bilateral pleural effusion were significantly more frequent non-survivors than survivors (p<0.02 p=0.0006, respectively). Also, mean admission levels thrombin-antithrombin complexes (TATc) plasminogen activator inhibitor type 1 (PAI-1), activation markers coagulation fibrinolysis, respectively, higher (p=0.004 In regression analysis, TATc associated mortality (p=0.007 p=0.048, Conclusions: Our data provide evidence for relationship effusion, marker leakage, activation, both characteristic syndrome. Keywords: syndrome, mortality, risk factor. ABSTRAK Faktor risiko kematian pada demam berdarah dengan sindroma syok Latar belakang: DSS merupakan bentuk klinik yang paling berat dari (DBD) dan mempunyai angka tinggi. Terdapat dua kelainan patologik utama DBD menentukan beratnya penyakit, yakni kebocoran perdarahan. Sitokine dilepas sewaktu terjadi respon imun diduga mediator proses ini. Metode: Studi dilaksanakan penderita anak, dimana diantaranya meninggal. Investigasi dilakukan untuk mencari temuan laboratorik berhubungan kematian. Hasil: Perdarahan efusi pleura secara bermakna lebih banyak ditemukan meninggal dibandingkan hidup (berturut-turut p<0,02 p=0,0006). Rerata kadar masuk rumah sakit (PAI-1) juga petanda aktivasi koagulasi fibrinolisis, p=0,004 p=0,0006) tinggi Pada analisis regresi didapatkan bahwa p=0,007 p=0,048). Simpulan: Data studi ini membuktikan adanya hubungan antara (suatu plasma) keduanya khas DSS.