Intestinal Host Response to SARS-CoV-2 Infection and COVID-19 Outcomes in Patients With Gastrointestinal Symptoms.

摘要: Background & Aims Given that gastrointestinal (GI) symptoms are a prominent extrapulmonary manifestation of COVID-19, we investigated intestinal infection with SARS-CoV-2, its effect on pathogenesis, and clinical significance. Methods Human biopsy tissues were obtained from patients COVID-19 (n =19) uninfected control individuals (n = 10) for microscopic examination, cytometry by time flight analyses, RNA sequencing. Additionally, disease severity mortality examined in without GI 2 large, independent cohorts hospitalized the United States 634) Europe 287) using multivariate logistic regressions. Results case cohort comparable age, sex, rates hospitalization, relevant comorbid conditions. SARS-CoV-2 was detected small epithelial cells immunofluorescence staining or electron microscopy 14 16 studied. High-dimensional analyses showed low levels inflammation, including down-regulation key inflammatory genes IFNG, CXCL8, CXCL2, IL1B reduced frequencies proinflammatory dendritic compared individuals. Consistent these findings, found significant reduction presenting illnesses despite similar nasopharyngeal viral loads. Furthermore, there proteins circulation symptoms. Conclusions These data highlight absence response tract detection SARS-CoV-2. In parallel, observed. A potential role attenuating SARS-CoV-2–associated inflammation needs to be further examined.