Alzheimer's disease versus Dementia with Lewy bodies : Cerebral metabolic distinction with autopsy confirmation

摘要: Seeking antemortem markers to distinguish Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), we examined brain glucose metabolism of DLB AD. Eleven patients (7 body variant AD [LBVAD] 4 pure diffuse [DLBD]) who had position emission tomography imaging autopsy confirmation were compared 10 autopsy-confirmed patients. In addition, 53 clinically-diagnosed probable AD, 13 whom later fulfilled clinical diagnoses DLB, examined. Autopsy-confirmed showed significant metabolic reductions involving parietotemporal association, posterior cingulate, frontal association cortices. Only in the occipital cortex, particularly primary visual cortex (LBVAD -23% DLBD -29% vs -8%), which distinguished versus 90% sensitivity 80% specificity. Multivariate analysis revealed that changes independent from those adjacent Analysis clinically diagnosed a significantly higher frequency reduction among criteria for DLB. these patients, hypometabolism preceded some features Occipital is potential marker