Investigating the effect of liposomal membrane fluidity and antibody lateral mobility on endothelial cell targeting

摘要: Atherosclerosis is initiated by the adhesion of leukocytes to endothelial surface arteries followed migration beneath intima. Current therapies combat atherosclerotic plaque, such as statins or antihypertensive drugs, treat atherosclerosis indirectly; they do not specifically target inflamed vasculature improve vascular condition. Few studies have focused on antibody mobility membrane fluidity an approach drug delivery vehicle binding and uptake. Here, we present a biomimetic liposomal design targeting molecule (VCAM1) E-selectin, which are upregulated cells (ECs). We hypothesized that increased lateral diffusivity may be used strategy enhance liposome ECs expressing high levels VCAM1 Eselectin. first characterized physical properties our system, including quantification density, evaluated temporal EC expression E-selectin. then examined effects fluidity, incubation time activated Finally, also conducted preliminary in vivo study where assessed biodistribution liposomes.