Self-Assembled Thermoresponsive Nanogel from Grafted Hyaluronic Acid as a Biocompatible Delivery Platform for Curcumin with Enhanced Drug Loading and Biological Activities
作者： Jittima Amie Luckanagul , Pahweenvaj Ratnatilaka Na Bhuket , Chawanphat Muangnoi , Pranee Rojsitthisak , Qian Wang
关键词: Drug 、 Artificial skin 、 Dynamic light scattering 、 Hyaluronic acid 、 Curcumin 、 Nanogel 、 Chemistry 、 Aqueous solution 、 Chemical engineering 、 HaCaT
摘要: A hyaluronic acid-grafted poly(N-isopropylacrylamide) (HA-pNIPAM) was synthesized as a polymeric nanogel platform for encapsulation and delivery of hydrophobic bioactive compounds using curcumin model drug. As demonstrated by transmission electron microscopy dynamic light scattering techniques, the HA-pNIPAM simply assembled into spherical nano-sized particles with thermoresponsive behavior. The success aqueous solubilization confirmed fluorescent spectroscopy. resulting formulation enhanced solubility uptake NIH-3T3 cells curcumin. This also demonstrates cytocompatibility against cells, which deems it safe vehicle. Moreover, has slight skin-protection effect an artificial skin equivalence model. curcumin-loaded showed anti-proliferative activity MDA-MB-231, Caco-2, HepG2, HT-29, TNF-α-induced hyperproliferation keratinocyte (HaCaT) cells. reported here could be further optimized controlled-release systems to encapsulate pharmaceuticals therapeutic applications.
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