Maternal BMI, Mid-pregnancy Fatty Acid Concentrations,and Perinatal Outcomes.

摘要: Abstract Purpose Maternal body mass index (BMI) and systemic fatty acid (FA) concentrations affect inflammatory balance in pregnancy play a key role fetal growth well-being. Little is known about how maternal BMI may the association between FA neonatal outcomes. The objective of this study was to examine associations omega (n)6:n3 ratio outcomes according pre-pregnancy category. Methods This secondary analysis Maternal-Fetal Medicine Units Network randomized controlled trial omega-3 supplementation prevent recurrent preterm birth. At consent (16–22 weeks pregnancy), women were either intervention arm (2 g n3 FAs) or control (placebo). For present analysis, primary exposure proinflammatory anti-inflammatory (n6:n3) FAs at 25 28 pregnancy. outcome as measured by using birth-weight-for-gestational-age z score, birth-length-for-gestational-age head-circumference-for-gestational-age score. categories defined lean (18.5–24.9 kg/m²) overweight/obese (OWOB) (≥25.0 kg/m²). Final stratified adjusted for education, race, parity, smoking status, total fish intake time blood draw, number days delivery. Findings A 440 participants included analysis; 49% lean, 51% OWOB. After adjustment covariates, higher n6:n3 associated with impaired (birth-weight-for-gestational-age β = –0.04 per unit increase n6:n3; 95% CI, –0.07 –0.01), 1 day shorter length gestation (β = –0.14 week; –0.27 incidence respiratory distress syndrome (odds ratio, 1.37; 1.04 1.80), increased hospital stay (β = 0.29 day; 0.003 0.58) OWOB, but not participants. Implications Higher inflammation during pregnancy, be marker adverse perinatal outcomes, particularly among OWOB women.