Animals as sentinels of human health hazards of environmental chemicals.

摘要: A workshop titled "Using Sentinel Species Data to Address the Potential Human Health Effects of Chemicals in Environment," sponsored by U.S. Army Center for Environmental Research, National Assessment EPA, and Agency Toxic Substances Disease Registry, was held consider use sentinel surrogate animal species data evaluating potential human health effects chemicals environment. The took a broad view concept, included mammalian nonmammalian species, companion animals, food fish, amphibians, other wildlife. observations wild animals field situations as well experimental data. Workshop participants identified applications derived from monitoring programs or serendipitous explored such information hazard risk assessments causes mechanisms effect. Although it is unlikely that will be used sole determinative factor concerns, can useful additional weight evidence assessment, providing early warning requiring further study, course remedial activities. Attention given factors impeding application approaches their acceptance scientific regulatory communities. number critical research needs opportunities interagency collaboration could help advance approaches.