ANTI-INFECTIVE PROTECTIVE PROPERTIES OF S100 CALGRANULINS.

摘要: The calgranulins are a subgroup of proteins in the S100 family (calgranulin A, S100A8; calgranulin B, S100A9 and C, S100A12) that provide protective anti-infective anti-inflammatory functions for mammalian host. In this review, we discuss structure-function relationships whereby S100A8 S100A9, comparison, S100A12, intra- extracellular protection during complex interplay between infection inflammation how regulated to optimally protect Ideally located support epithelial barrier function, calprotectin, S100A8/S100A9, is expressed squamous mucosal keratinocytes innate immune cells present at surfaces. also abundantly produced neutrophils monocytes, whereas expression induced epidermal keratinocytes, gastrointestinal fibroblasts inflammation. show species-specific function. For example, chemotactic rodents but not humans. humans, S100A12 appears serve as functional homolog murine S100A8. Transition metal-binding oxidation sites within able create structural changes may orchestrate new or binding targets. thus appear adopt variety roles addition serving leukocyte chemoattractant, include oxidant scavenging, antimicrobial activity, chemokine-like activities. Each function reflect concentration calgranulin, post-transcriptional modifications, oligomeric forms, proximal intracellular environments. Calprotectin remarkable multifunctional dedicated protecting environments