Toxicity of imidazoles ionic liquid [C16mim]Cl to Hela cells.
作者： Xiaohua Xia , Ruyan Wan , Peijin Wang , Weiran Huo , Hui Dong
DOI: 10.1016/J.ECOENV.2018.07.022
关键词: Molecular biology 、 Oxidative stress 、 Genotoxicity 、 Apoptosis 、 Glutathione 、 Superoxide dismutase 、 Cytotoxicity 、 HeLa 、 Viability assay 、 Chemistry
摘要: Abstract Our study aimed to evaluate the toxicity of 1-hexadecyl-3-methylimidazolium chloride ([C16min]Cl) on human cervical carcinoma (Hela) cells. We evaluated toxicity, cell viability, genotoxicity, oxidative stress, apoptosis, and apoptosis-related gene expression in Hela cells following exposure [C16min]Cl. The results indicated that [C16min]Cl inhibited growth cells, decreased induced DNA damage superoxide dismutase, glutathione content, as well increased cellular malondialdehyde level Moreover, changes transcription p53, Bax Bcl-2, suggesting p53 Bcl-2 family might have been involved cytotoxicity apoptosis by Taken together, these revealed imparts induces cells; hence, it is not a green solvent.
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