1,25,26-trihydroxyvitamin D3: Isolation, identification, and biological activity
作者： Yoko Tanaka , Heinrich K. Schnoes , Connie M. Smith , Hector F. Deluca
DOI: 10.1016/0003-9861(81)90169-7
关键词: In vitro 、 Vitamin 、 Metabolite 、 Periodate 、 Chromatography 、 Chemistry 、 Biochemistry 、 Biological activity 、 Stimulation 、 Kidney 、 Calcium 、 Biophysics 、 Molecular biology
摘要: Abstract A polar metabolite of vitamin D3 has been produced in vitro from either 1,25-dihydroxyvitamin incubated with kidney homogenate D-supplemented chickens or 25,26-dihydroxyvitamin D-deficient chicken homogenate. This compound was isolated pure form and identified as 1,25,26-trihydroxyvitamin by ultraviolet absorption spectrophotometry mass spectrometry. Furthermore, its periodate cleavage product comigrates synthetic 1α-hydroxy-25-keto-27-norvitamin on high-performance liquid chromatography. The is 0.1-0.01 active the stimulation intestinal calcium transport bone mobilization.
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