SARS-CoV-2 and coagulation disorders in different organs.

摘要: Coronavirus disease 2019 (COVID-19) is a prominent pandemic that emerged in China and hurriedly stretched worldwide. There are many reports on COVID-19 associated with the amplified incidence of thrombotic events. In this review, we focused coupled coagulopathy contributes to severe outcome inclusive comorbidities such as venous thromboembolism, stroke, diabetes, lung, heart attack, AKI, liver injury. Initially, patient coagulation disorders show an elevated level D-dimer, fibrinogen, less lymphocyte count lymphopenia. Kawasaki has acute vasculitis childhood which further affects vessels found all over body. linked microangiopathy triggers multiple along arterioles thrombosis, medium, large arterial mediates disseminated intravascular (DIC). SARS-Co-V-2 patients have reduced primary platelet production, increased destruction platelet, decreased circulating leads condition thrombocytopenia disorder. Endothelial dysfunction plays important role via generation thrombin stops fibrinolysis hypercoagulopathy. Along endothelial activates complement system pathways chronic inflammation cytokine storm production cytokines chemokines, different organs brain, liver, heart, kidney multi-organ failure.