Allosteric signal-amplification sensing with polymer-based supramolecular hosts

摘要: The lock-and-key principle is a fundamental substance to create chemosensors that sense target analytes. Our results based on the concept, i.e., inherently chiral molecular clips and resorcin[4]arenes, were introduced their inherent problems also explained. Hence, novel sensing methodology, “supramolecular allosteric signal-amplification sensing” (SASS), has been proposed develop functional polythiophenes polysaccharides for amino acids, peptides, oligosaccharides are difficult sense. polythiophene sensors showed amplified responses through positive allosterism, polysaccharide capture in aqueous media then expanded an extremely sensitive situ oligosaccharide sensor dynamically controllable. present SASS strategy using polymer behave very differently from common ones essentially allosterically information propagation, upon interaction of analyte chemosensor’s binding pocket, amplifying reporter.