Role of B-RafV600E in differentiated thyroid cancer and preclinical validation of compounds against B-RafV600E
作者： Carmelo Nucera , Melanie Goldfarb , Richard Hodin , Sareh Parangi
DOI: 10.1016/J.BBCAN.2009.01.003
关键词: Cancer research 、 Lymph node 、 Thyroid cancer 、 Papillary thyroid cancer 、 Thyroid 、 Kinase 、 V600E 、 MAPK/ERK pathway 、 Medicine 、 Thyroid carcinoma
摘要: B-Raf(V600E), an oncogenic protein kinase, is the most frequent genetic alteration in papillary thyroid carcinomas (PTC). PTC represents 80-90% of all cancers and over past five years, more than 200 manuscripts have been published about relationship between "B-Raf(V600E) cancer". B-Raf(V600E) genetically arises from a transversion point mutation (valine-to-glutamate substitution at amino acid residue-600, V600E) leads to activation mitogen-activated kinases (MAPK) signaling pathway. The MAPK pathway essential for transmitting proliferation signals generated by cell surface receptors cytoplasmic elements nucleus. In many cancers, including cancer, appears play crucial role proliferation, survival de-differentiation. V600E occurs with greater frequently aggressive subtypes PTC, individuals that present advanced stages disease extra-thyroidal extension and/or lymph node metastases. considered marker both (>1 cm) micro-PTC (
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