A Dual Bioconjugated Virus-Like Nanoparticle as a Drug Delivery System and Comparison with a pH-Responsive Delivery System

摘要: Modifications of virus-like nanoparticles (VLNPs) using chemical conjugation techniques have brought the field virology closer to nanotechnology. The huge surface area volume ratio VLNPs permits multiple copies a targeting ligand and drugs be attached per nanoparticle. By exploring chemistry truncated hepatitis B core antigen (tHBcAg) VLNPs, doxorubicin (DOX) was coupled covalently external these via carboxylate groups. About 1600 DOX molecules were conjugated on each tHBcAg VLNP. Then, folic acid (FA) lysine residues target cancer cells over-expressing receptor (FR). result demonstrated that dual bioconjugated increased accumulation uptake in human cervical colorectal cell lines compared with free DOX, resulting enhanced cytotoxicity towards cells. fabrication is simple, can easily high coupling efficacy without any limitation respect cargo’s size or charge, as pH-responsive system based VLNPs. These also potential modified for other combinatorial drug deliveries.