Chapter 14 Metabotropic glutamate receptors and neurodegeneration
作者： Valeria Bruno , Giuseppe Battaglia , Agata Copani , Giacomo Casabona , Marianna Storto
DOI: 10.1016/S0079-6123(08)60439-2
关键词: Metabotropic glutamate receptor 、 Metabotropic glutamate receptor 7 、 Metabotropic glutamate receptor 1 、 Metabotropic glutamate receptor 4 、 Neuroscience 、 Long-term depression 、 Pharmacology 、 Metabotropic glutamate receptor 5 、 Class C GPCR 、 Metabotropic glutamate receptor 2 、 Biology
摘要: Metabotropic glutamate (mGlu) receptors, which exert a modulatory effect on excitatory synaptic transmission, are considered as potential targets for neuroprotective drugs and the advent of potent centrally available subtype-selective ligands has lead to an extensive investigation role individual mGlu receptor subtypes in neurodegeneration . Pharmacological blockade I or -5 receptors pharmacologica l activation mGlu2/3 mGlu4/7/8 produces neuroprotection variety vitro vivo models. MGlul antagonists promising treatment brain ischemia prophylaxis neuronal damage induced by hyperactivity. MGlu5 may limit hyperactivity NMDA because mGlu5 physically functionally connected membranes, suggesting application chronic neurodegenerative disorders, such Amyotrophic Lateral Sclerosis (ALS) Alzheimer's disease (AD). MGlu2/3 agonists inhibit release, also promote synthesis release neurotrophic factors astrocytes. These therefore have broad agents eNS disorders Finally, potently seizure disorders.
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sci-hub.se 参考文章(135)
Walter J. Koroshetz, Michael A. Moskowitz, Emerging treatments for stroke in humans Trends in Pharmacological Sciences. ,vol. 17, pp. 227- 233 ,(1996) , 10.1016/0165-6147(96)10020-1
Alain Buisson, Shan Ping Yu, Dennis W. Choi, DCG-IV selectively attenuates rapidly triggered NMDA-induced neurotoxicity in cortical neurons. European Journal of Neuroscience. ,vol. 8, pp. 138- 143 ,(1996) , 10.1111/J.1460-9568.1996.TB01174.X
Stephen P. Squinto, Thomas H. Aldrich, Ronald M. Lindsay, Donna M. Morrissey, Nikos Panayotatos, Stella M. Bianco, Mark E. Furth, George D. Yancopoulos, Identification of functional receptors for ciliary neurotrophic factor on neuronal cell lines and primary neurons. Neuron. ,vol. 5, pp. 757- 766 ,(1990) , 10.1016/0896-6273(90)90334-C
Ann Bond, Nella Ragumoorthy, James A. Monn, Caroline A. Hicks, Mark A. Ward, David Lodge, Michael J. O'Neill, LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia Neuroscience Letters. ,vol. 273, pp. 191- 194 ,(1999) , 10.1016/S0304-3940(99)00663-1
I. Brabet, S. Mary, J. Bockaert, J.-P. Pin, Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses Neuropharmacology. ,vol. 34, pp. 895- 903 ,(1995) , 10.1016/0028-3908(95)00079-L
Z. Nusser, E. Mulvihill, P. Streit, P. Somogyi, Subsynaptic segregation of metabotropic and ionotropic glutamate receptors as revealed by immunogold localization Neuroscience. ,vol. 61, pp. 421- 427 ,(1994) , 10.1016/0306-4522(94)90421-9
Marina Pizzi, Ornella Consolandi, Maurizio Memo, PierFranco Spano, Activation of multiple metabotropic glutamate receptor subtypes prevents NMDA-induced excitotoxicity in rat hippocampal slices. European Journal of Neuroscience. ,vol. 8, pp. 1516- 1521 ,(1996) , 10.1111/J.1460-9568.1996.TB01614.X
A. Ugolini, M. Corsi, F. Bordi, Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurons Neuropharmacology. ,vol. 38, pp. 1569- 1576 ,(1999) , 10.1016/S0028-3908(99)00095-7
Roger L. Albin, Anne B. Young, John B. Penney, The functional anatomy of basal ganglia disorders. Trends in Neurosciences. ,vol. 12, pp. 366- 375 ,(1989) , 10.1016/0166-2236(89)90074-X
V Bruno, G Battaglia, A Kingston, M.J O’Neill, M.V Catania, R Di Grezia, F Nicoletti, Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors. Neuropharmacology. ,vol. 38, pp. 199- 207 ,(1999) , 10.1016/S0028-3908(98)00159-2