Superior memory and higher cortical volumes in unusually successful cognitive aging.

摘要: It is "normal" for old age to be associated with gradual decline in memory and brain mass. However, there are anecdotal reports of individuals who seem immune age-related impairment, but these have not been studied systematically. This study sought establish that such cognitive SuperAgers exist determine if they were also resistant loss cortical volume. defined as over 80 episodic performance at least good normative values 50- 65-year-olds. Cortical morphometry the was compared two cognitively normal cohorts: age-matched elderly The SuperAgers' cerebral cortex significantly thicker than their healthy peers displayed no atrophy 65-year-old group. Unexpectedly, a region left anterior cingulate both middle-aged controls. Our findings identify neuroanatomical features cohort appears resist average changes capacity A better understanding underlying factors promoting this potential trajectory unusually successful aging may provide insight preventing impairments or more severe Alzheimer's disease.