Scale-up strategy for continuous powder blending process
作者： Yijie Gao , Fernando J. Muzzio , Marianthi G. Ierapetritou
DOI: 10.1016/J.POWTEC.2012.09.036
关键词: Computer science 、 Process engineering 、 Simulation 、 Mixing (physics) 、 Scaling 、 Variance (accounting) 、 Residence time distribution 、 Characterization (materials science) 、 SCALE-UP 、 Work (thermodynamics) 、 Process (computing)
摘要: Abstract Continuous powder mixing has attracted a lot of interest within the pharmaceutical industry. Much work been done recently that targets characterization continuous mixing. In this paper, quantitative scaling up strategy is introduced allows transition from lab to industrial scale. The proposed methodology based on variance spectrum analysis, and residence time distribution, which are key indexes in capturing scale-up batch-like mixing, axial motion, respectively. Our simulation results used as preliminary guidance for different cases.
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