Platelet diameters in inherited thrombocytopenias: analysis of 376 patients with all known disorders

摘要: Abnormalities of platelet size are one the distinguishing features inherited thrombocytopenias (ITs), and evaluation blood films is recommended as an essential step for differential diagnosis these disorders. Nevertheless, what we presently know about this subject derived mainly from anecdotal evidence. To improve knowledge in field, evaluated on obtained 376 patients with all 19 forms IT identified so far found that conditions differ not only mean diameter, but also diameter distribution width percentage platelets increased or reduced diameters. On basis findings, propose a new classification ITs according to size. It distinguishes giant platelets, large normal slightly size, decreased We measured diameters 87 immune thrombocytopenia cutoff values have good diagnostic accuracy differentiating other IT.