Engineering the acoustic response of lipid‐based microbubbles: Simulations and high speed optical imaging results

摘要: Gas microbubbles coated with a surfactant or polymer shell have become well established as contrast agents for ultrasound imaging and are under investigation therapeutic applications such targeted drug delivery. The purpose of this study was to examine the effect modifying microbubbles’ coating composition upon their response excitation. Using high speed camera operating at 3 MHz, radial oscillations from commercial agent SonoVueTM four in‐house microbubble preparations were measured controlled insonation conditions (four‐cycle Gaussian pulse; center frequency 0.5 MHz; peak negative pressure 30–70 kPa). results indicate that varies lipid structure functional components in change. These findings been compared simulation using generalized model dynamics developed by authors, order quantify observed effects changing micr...