Hematologic side effects of interferon and ribavirin therapy.

摘要: Pegylated (PEG)-interferon and ribavirin combination therapy are the standard of care for treatment chronic hepatitis C associated with a high rate sustained virologic response. However, there is incidence hematologic side effects this therapeutic regimen. Hematologic particularly common; bone marrow suppression caused by interferon may result in neutropenia thrombocytopenia. Ribavirin directly toxic to red blood cells hemolysis, which usually dose-related but self-limited. Historically, traditional management has been dose reduction. recent studies have shown that response strongly influenced adherence optimal doses ribavirin. Therefore, increasing emphasis on use growth factors such as filgrastim erythropoietin stimulate production erythrocytes leukocytes allow patients receive The incidence, magnitude, possible mechanisms complications described review.