Multifocal Primary Prostate Cancer Exhibits High Degree of Genomic Heterogeneity.

摘要: Abstract Background Most primary prostate cancers are multifocal with individual tumors harboring different aggressiveness; however, the genomic heterogeneity among these is poorly understood. Objective To better understand biological basis for clinical variability lesions, we sought to comprehensively characterize of somatic gene mutations in cancer. Design, setting, and participants High-coverage whole-exome sequencing 153 frozen tissue samples, taken from two three distinct tumor foci one non-cancerous area each 41 patients, covering a total 89 foci. Outcome measurements statistical analysis State-of-the-art bioinformatics tools mutation calling copy number determination data. Results limitations We found very high degree interfocal tumors, that is, 76% pairwise-compared same prostatectomy specimen had no point common DNA changes were rarely shared across cancer The few seldom cancer-critical genes. Conclusions In this first large study cancer, observe within patient genetically distinct, only sharing any mutations, including those driver This affects how genomics-based management can be implemented, as information all necessary draw valid conclusions about cancer's alterations. Patient summary consist multiple organ, but little known their relationships. have compared sets such they exceptionally common. will influence treatment decisions future tumor's render it unique considered gain best results.