Radiotherapy with BRAF inhibitor therapy for melanoma: progress and possibilities
作者： Sebastian Zahnreich , Arnulf Mayer , Carmen Loquai , Stephan Grabbe , Heinz Schmidberger
DOI: 10.2217/FON.15.297
关键词: Medicine 、 Combined Modality Therapy 、 Vemurafenib 、 Targeted therapy 、 Oncology 、 BRAF inhibitor 、 Radiation therapy 、 Dabrafenib 、 Internal medicine 、 Melanoma 、 Concomitant
摘要: The introduction of small molecule BRAF(V600) kinase inhibitors represents a milestone in the targeted therapy patients with metastatic melanoma by significant increase therapeutic efficacy terms overall and progression-free survival compared conventional chemotherapy. Beside inhibitor treatment, radiotherapy is further mainstay for thus concomitant or sequential application inevitable. Recent reports show radiosensitization irradiated healthy tissue after combination inhibitors, evoking concern clinical practice. We review interactions radiation regard to antitumor effects an increased radiotoxicity tissue.
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sci-hub.se 参考文章(82)
Ricarda Merten, Markus Hecht, Marlen Haderlein, Luitpold Distel, Rainer Fietkau, Lucie Heinzerling, Sabine Semrau, Increased skin and mucosal toxicity in the combination of vemurafenib with radiation therapy. Strahlentherapie Und Onkologie. ,vol. 190, pp. 1169- 1172 ,(2014) , 10.1007/S00066-014-0698-X
Weijiang Zhang, BRAF inhibitors: the current and the future. Current Opinion in Pharmacology. ,vol. 23, pp. 68- 73 ,(2015) , 10.1016/J.COPH.2015.05.015
Claire Vanpouille-Box, Karsten A. Pilones, Erik Wennerberg, Silvia C. Formenti, Sandra Demaria, In situ vaccination by radiotherapy to improve responses to anti-CTLA-4 treatment. Vaccine. ,vol. 33, pp. 7415- 7422 ,(2015) , 10.1016/J.VACCINE.2015.05.105
B. Schulze, M. Meissner, M. Wolter, C. Rödel, C. Weiss, Unusual acute and delayed skin reactions during and after whole-brain radiotherapy in combination with the BRAF inhibitor vemurafenib. Two case reports. Strahlentherapie Und Onkologie. ,vol. 190, pp. 229- 232 ,(2014) , 10.1007/S00066-013-0474-3
Klaus K. Herfarth, Oxana Izwekowa, Christoph Thilmann, Andrea Pirzkall, Stefan Delorme, Udo Hofmann, Dirk Schadendorf, Dietmar Zierhut, Michael Wannenmacher, Jürgen Debus, Linac-Based Radiosurgery of Cerebral Melanoma Metastases Strahlentherapie Und Onkologie. ,vol. 179, pp. 366- 371 ,(2003) , 10.1007/S00066-003-1050-Z
Barouyr Baroudjian, Lise Boussemart, Emilie Routier, Brigitte Dreno, Yungan Tao, Eric Deutsch, Pierre Blanchard, Frédéric Dhermain, Laurence Vilcot, Stephan Vagner, Alexander Eggermont, Christine Mateus, Caroline Robert, Dramatic response to radiotherapy combined with vemurafenib. Is vemurafenib a radiosensitizer European Journal of Dermatology. ,vol. 24, pp. 265- 267 ,(2014) , 10.1684/EJD.2014.2300
Anne-Lise Ruellan, François Thillays, Gaëlle Quereux, Anabelle Brocard, Mélanie Saint-Jean, Maud Aumont, Franck Drouet, Brigitte Dreno, Lucie Peuvrel, Severe radiotherapy-induced extracutaneous toxicity under vemurafenib European Journal of Dermatology. ,vol. 23, pp. 879- 881 ,(2013) , 10.1684/EJD.2013.2193
Connie M Wang, Sylvia Hsu, Kristy F Fleming, A case of vemurafenib-induced keratosis pilaris-like eruption Dermatology Online Journal. ,vol. 18, pp. 7- ,(2012)
John T. Lee, Ling Li, Patricia A. Brafford, Marcia van den Eijnden, Molly B. Halloran, Katrin Sproesser, Nikolas K. Haass, Keiran S.M. Smalley, James Tsai, Gideon Bollag, Meenhard Herlyn, PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas. Pigment Cell & Melanoma Research. ,vol. 23, pp. 820- 827 ,(2010) , 10.1111/J.1755-148X.2010.00763.X
Steve Boudewijns, Winald R Gerritsen, Rutger sH T Koornstra, Case series: indoor-photosensitivity caused by fluorescent lamps in patients treated with vemurafenib for metastatic melanoma BMC Cancer. ,vol. 14, pp. 967- 967 ,(2014) , 10.1186/1471-2407-14-967