Intraperitoneal Delivery of Cisplatin via a Hyaluronan-Based Nanogel/in Situ Cross-Linkable Hydrogel Hybrid System for Peritoneal Dissemination of Gastric Cancer.
作者： Seiichi Ohta , Shota Hiramoto , Yuki Amano , Shigenobu Emoto , Hironori Yamaguchi
DOI: 10.1021/ACS.MOLPHARMACEUT.7B00349
关键词: Drug 、 Nanogel 、 In situ 、 Chemical conjugation 、 Chemistry 、 Chelating ligands 、 Self-healing hydrogels 、 Cisplatin 、 Pharmacology 、 Nanotechnology 、 Peritoneal cavity
摘要: Intraperitoneal administration of chemotherapeutics is expected for the treatment peritoneally disseminated gastric cancer because poor migration drugs from systemic circulation to peritoneal cavity. In this study, intraperitoneal delivery cisplatin (CDDP), we developed a hyaluronan (HA)-based hybrid system in which CDDP-loaded HA nanogels were either physically encapsulated or chemically conjugated injectable hydrogels. Physical encapsulation enabled sustained release hydrogel matrix over week. This was longer period than that free CDDP, released 80% drug 2 days. The attributed delayed diffusion network. profile could be tuned by modifying chemical conjugation matrix, as well type chelating ligands used load CDDP nanogel. Furthermore, intraperitoneally administered...
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