Middle Ear Effusion in Children With Congenital Cytomegalovirus Infection.

作者: Martha D. Yow , Winnie Chung , Jessica Leung , Tatiana M. Lanzieri , Peggy Blum

DOI: 10.1097/INF.0000000000002564

关键词: PediatricsConfidence intervalEar canalMedicineSensorineural hearing lossAsymptomaticPopulationCongenital cytomegalovirus infectionOdds ratioHearing aid

摘要: Background Sensorineural hearing loss (SNHL) is well described in children with congenital cytomegalovirus (CMV) infection, but limited data are available on middle ear effusion (MEE) occurrence this population. We assessed the prevalence of MEE and degree transient change associated among CMV infection. Methods Children infection enrolled a longitudinal study received tympanometric testing during scheduled follow-up visits annually up to 6 years age. used generalized linear mixed-effect logistic regression model compare odds MEE, defined as type B tympanogram (normal canal volume little tympanic membrane movement) patients categorized symptomatic or asymptomatic based presence CMV-associated signs newborn period. Results Forty-four (61%) 72 24 (28%) 87 had ≥1 visit MEE. After controlling for number visits, significantly higher (odds ratio: 2.09; 95% confidence interval: 1.39-3.14) than patients. Transient decrease ranged from 10 40 dB, measured by audiometric air-bone gap 11 Conclusions Among CMV, can result decrease, which reduce efficacy aid those SNHL. It warranted that SNHL receive routine audiologic better manage amplification levels.

参考文章(25)
Aao-Hns, Matthew J Neff, Aap, Aafp, AAP, AAFP, AAO-HNS release guideline on diagnosis and management of otitis media with effusion. American Family Physician. ,vol. 69, pp. 2929- ,(2004)
S B Boppana, W J Britt, R F Pass, K B Fowler, J D Wright, A J Dahle, Longitudinal investigation of hearing disorders in children with congenital cytomegalovirus. Journal of The American Academy of Audiology. ,vol. 11, pp. 283- 290 ,(2000)
David W. Teele, Jerome O. Klein, Bernard A. Rosner, Epidemiology of otitis media in children. The Annals of otology, rhinology & laryngology. Supplement. ,vol. 89, pp. 5- 6 ,(1980) , 10.1177/00034894800890S304
Eleni Rettig, David E. Tunkel, Contemporary Concepts in Management of Acute Otitis Media in Children Otolaryngologic Clinics of North America. ,vol. 47, pp. 651- 672 ,(2014) , 10.1016/J.OTC.2014.06.006
GERHARD A. ZIELHUIS, GEROLD H. RACH, PAUL BROEK, The occurrence of otitis media with effusion in Dutch pre-school children. Clinical Otolaryngology. ,vol. 15, pp. 147- 153 ,(1990) , 10.1111/J.1365-2273.1990.TB00448.X
Peter F. Wright, Sarah H. Sell, Kathryn B. McConnell, Ann B. Sitton, Juliette Thompson, William K. Vaughn, Fred H. Bess, Impact of recurrent otitis media on middle ear function, hearing, and language. The Journal of Pediatrics. ,vol. 113, pp. 581- 587 ,(1988) , 10.1016/S0022-3476(88)80659-0
G. S. Takata, L. S. Chan, T. Morphew, R. Mangione-Smith, S. C. Morton, P. Shekelle, Evidence assessment of the accuracy of methods of diagnosing middle ear effusion in children with otitis media with effusion. Pediatrics. ,vol. 112, pp. 1379- 1387 ,(2003) , 10.1542/PEDS.112.6.1379
Richard M. Rosenfeld, Larry Culpepper, Karen J. Doyle, Kenneth M. Grundfast, Alejandro Hoberman, Margaret A. Kenna, Allan S. Lieberthal, Martin Mahoney, Richard A. Wahl, Charles R. Woods, Barbara Yawn, Clinical Practice Guideline: Otitis Media with Effusion Otolaryngology-Head and Neck Surgery. ,vol. 130, ,(2004) , 10.1016/J.OTOHNS.2004.02.002
C BLUESTONE, W DOYLE, Anatomy and physiology of eustachian tube and middle ear related to otitis media The Journal of Allergy and Clinical Immunology. ,vol. 81, pp. 997- 1003 ,(1988) , 10.1016/0091-6749(88)90168-6
J. L. Paradise, H. E. Rockette, D. K. Colborn, B. S. Bernard, C. G. Smith, M. Kurs-Lasky, J. E. Janosky, Otitis Media in 2253 Pittsburgh-Area Infants: Prevalence and Risk Factors During the First Two Years of Life Pediatrics. ,vol. 99, pp. 318- 333 ,(1997) , 10.1542/PEDS.99.3.318