Effects of Malassezia yeasts on serum Th1 and Th2 cytokines in patients with guttate psoriasis

摘要: Background  Systemic and focal infections caused by microorganisms have been known to induce or exacerbate psoriasis. Although the role of yeast species genus Malassezia in pathogenesis psoriasis is not fully understood, it thought that these lipophilic yeasts may represent a triggering factor exacerbation psoriatic lesions. Objectives  This study investigated effects on serum Th1 Th2 cytokines patients with guttate (GP) order define their psoriasis. Methods  Fifty GP 29 clinically healthy individuals were included study. All samples consisted scales scrapings taken from scalps, trunks, upper limbs both subjects. Psoriasis subjects grouped according positivity negativity for as ascertained direct microscopy and/or culture. An enzyme-linked immunosorbent assay (ELISA) was used measure levels groups. Results  No significant differences found between skin different body sites. Serum interleukin-13 (IL-13) significantly lower group compared control (P = 0.04). Levels other did differ groups. Mean (IL-4, IL-10, IL-13), but (IL-2 IFN-γ), positive those negative (P = 0.04, P < 0.001 P = 0.01, respectively). Conclusions  The isolation lesions does necessarily mean are pathogenic, downregulating anti-inflammatory contribute occurrence GP.