Neuroprotective effects of female sex steroids in humans: current controversies and future directions.
作者： C. E. Gleason , B. Cholerton , C. M. Carlsson , S. C. Johnson , S. Asthana
DOI: 10.1007/S00018-004-4385-Z
关键词: Stroke 、 Epidemiology 、 Gynecology 、 Women's Health Initiative 、 Estrogen 、 Intensive care medicine 、 Hormone therapy 、 Dementia 、 Hormone replacement therapy (menopause) 、 Adverse effect 、 Medicine
摘要: Recent findings from the Women’s Health Initiative (WHI) have raised considerable concern over prolonged use of opposed and unopposed oral conjugated equine estrogen (CEE), given increased risk serious adverse effects, including stroke venous thromboembolic complications. Furthermore, results WHI Memory Study (WHIMS) indicated that 5 years therapy with Prempro impaired performance on global cognitive tests nearly doubled dementia. These surprising were contradictory to cumulative evidence basic science, epidemiological some intervention studies suggesting hormone was cardioprotective could potentially reduce This review paper focuses neurobiology estrogen, summarizing clinical for neuroprotective cognition-enhancing efficacy estrogen. Further, briefly discusses variables may account unexpected WHIMS, offers suggestions future research.
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sci-hub.se 参考文章(204)
M Cristo, R A Lobo, W G Crary, E C Ditkoff, Estrogen improves psychological function in asymptomatic postmenopausal women. Obstetrics & Gynecology. ,vol. 78, pp. 991- 995 ,(1991)
G. Vanhulle, R. Demol, A Double-Blind Study into the Influence of Estriol on a Number of Psychological Tests in Post-menopausal Women Springer, Dordrecht. pp. 94- 99 ,(1976) , 10.1007/978-94-011-7179-3_17
Robert A. Greene, Estrogen and cerebral blood flow: a mechanism to explain the impact of estrogen on the incidence and treatment of Alzheimer's disease. International journal of fertility and women's medicine. ,vol. 45, pp. 253- 257 ,(2000)
Ronald F. Zec, Mehul A. Trivedi, The effects of estrogen replacement therapy on neuropsychological functioning in postmenopausal women with and without dementia: a critical and theoretical review. Neuropsychology Review. ,vol. 12, pp. 65- 109 ,(2002) , 10.1023/A:1016880127635
Masayoshi Yamaguchi, Ying Hua Gao, Anabolic effect of genistein and genistin on bone metabolism in the femoral-metaphyseal tissues of elderly rats: The genistein effect is enhanced by zinc Molecular and Cellular Biochemistry. ,vol. 178, pp. 377- 382 ,(1998) , 10.1023/A:1006809031836
Johannes A. Rhodin, Tom N. Thomas, Linda Clark, Amanda Garces, Margaret Bryant, In vivo cerebrovascular actions of amyloid β-peptides and the protective effect of conjugated estrogens Journal of Alzheimer's Disease. ,vol. 5, pp. 275- 286 ,(2003) , 10.3233/JAD-2003-5403
L. Rauramo, K. Lagerspetz, P. Engblom, R. Punnonen, The effect of castration and peroral estrogen therapy on some psychological functions. Frontiers of Hormone Research. ,vol. 3, pp. 94- 104 ,(1975) , 10.1159/000398269
I. Wickelgren, ESTROGEN RESEARCH: Brain Researchers Try to Salvage Estrogen Treatments Science. ,vol. 302, pp. 1138- 1139 ,(2003) , 10.1126/SCIENCE.302.5648.1138
Robert B. Gibbs, Oestrogen and the cholinergic hypothesis: implications for oestrogen replacement therapy in postmenopausal women. Novartis Foundation symposium. ,vol. 230, pp. 94- 111 ,(2008) , 10.1002/0470870818.CH8
J. Galen buckwalter, Valerie C. Crooks, Sean B. Robins, Diana B. Petitti, Hormone Use and Cognitive Performance in Women of Advanced Age Journal of the American Geriatrics Society. ,vol. 52, pp. 182- 186 ,(2004) , 10.1111/J.1532-5415.2004.52053.X