A communicational link between skeletal muscle, brain, and cells of the immune system.

作者: M. Parry-Billings , E. Blomstrand , N. McAndrew , E. Newsholme

DOI: 10.1055/S-2007-1024863

关键词: Muscle contractionMetabolismOvertrainingTryptophanSkeletal muscleAmino acidBiologyInternal medicineEndocrinologyImmune systemGlutamine

摘要: The present paper reviews evidence for the role of specific amino acids in etiology fatigue and overtraining syndrome athletes. An increase plasma concentration ratio free tryptophan: branched-chain may mediate an 5-HT synthesis brain thus induce during exercise. Glutamine is essential proper functioning cells immune system a decrease glutamine post-exercise impairment function. Branched-chain play central both these processes. Thus, they compete with tryptophan entry into brain. also be important precursors nitrogen skeletal muscle or control release from muscle. Consequently, metabolism glutamine, tryptophan, key to understanding some aspects immunosuppression that are very relevant athletic endeavor. They other physiological pathological conditions.

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