Resistance exercise and naproxen sodium: effects on a stable PGF2α metabolite and morphological adaptations of the upper body appendicular skeleton

摘要: Introduction Exercise-induced inflammation has been shown to be necessary for successful skeletal muscle regeneration post-injury. Accordingly, numerous investigations have demonstrated consequences of COX-inhibitors, anti-inflammatory drugs which prevent prostaglandin formation. In addition its roles in inflammation, F2α (PGF2α) also mediates vital regenerative processes The majority research report suppressing utilized acute injury models combination with COX-inhibitor administration. To address the limited investigating regular consumption COX-inhibitors over time exercising humans, purpose this study was determine effects a non-selective on PGF2α metabolite and morphological adaptations upper body appendicular skeleton during periodized resistance training. Twenty-three (N = 23) recreationally trained college-aged males were randomly assigned receive placebo (n 11) or naproxen sodium 12). Treatments prophylactically administered double-blind fashion supervised exercise performed twice per week 6 weeks. Venous blood sampled pre- post-exercise analyzed 13, 14-dihydro-15-keto using enzyme immunoassay. Factorial mixed-design repeated-measures ANOVAs examine relative changes plasma morphology training period.