δ-Carbolines and their ring-opened analogs: synthesis and evaluation against fungal and bacterial opportunistic pathogens.
作者： Tryphon K. Mazu , Jagan R. Etukala , Melissa R. Jacob , Shabana I. Khan , Larry A. Walker
DOI: 10.1016/J.EJMECH.2011.03.021
关键词: Chemical synthesis 、 Cryptolepine 、 Antibacterial agent 、 Gram-positive bacteria 、 Structure–activity relationship 、 Natural product 、 Biochemistry 、 Antimicrobial 、 Chemistry 、 Pharmacophore 、 Stereochemistry
摘要: Previous studies have indicated that the δ-carboline (2) ring system derived from the natural product cryptolepine (1) may represent a pharmacophore for anti-infective activity. This …
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