The dynamic relationship between B-cell populations in adults

摘要: B lymphocytes are produced throughout life by pri- mary B-cell production from haemopoietic cells in the mzrrow and through antigen-driven proliferation secondary lymphoid tissues. Only a small proportion of these newly ceils have more than brief lifespan as (Table 1). The minority that sur- vive, differentiate to become part relatively stable pools peripheral cells. In rodents, unless activated antigen, they an estimated