Multivalent protein binding and precipitation by self-assembling molecules on a DNA pentaplex scaffold.
作者： Brooke A. Rosenzweig , Nathan T. Ross , Debarati M. Tagore , Janarthanan Jayawickramarajah , Ishu Saraogi
DOI: 10.1021/JA809219P
关键词: Biophysics 、 Self assembling 、 Scaffold 、 Chemistry 、 Phosphocholine 、 Molecule 、 Plasma protein binding 、 Biochemistry 、 Biomolecule 、 Supramolecular assembly 、 A-DNA
摘要: A supramolecular assembly containing an isoguanosine pentaplex with both a "protein-binding" face and "reporter" has been generated. When phosphocholine is appended to the protein-binding this binds multivalently pentameric human C-reactive protein, biomolecule implicated in inflammation heart disease.
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sci-hub.se 参考文章(20)
Darren Thompson, Mark B Pepys, Steve P Wood, The physiological structure of human C-reactive protein and its complex with phosphocholine. Structure. ,vol. 7, pp. 169- 177 ,(1999) , 10.1016/S0969-2126(99)80023-9
Hong Ling, Navraj S. Pannu, Randy J. Read, David R. Bundle, Pavel I. Kitov, Joanna M. Sadowska, George Mulvey, Glen D. Armstrong, Shiga-like toxins are neutralized by tailored multivalent carbohydrate ligands Nature. ,vol. 403, pp. 669- 672 ,(2000) , 10.1038/35001095
P. I. Kitov, G. L. Mulvey, T. P. Griener, T. Lipinski, D. Solomon, E. Paszkiewicz, J. M. Jacobson, J. M. Sadowska, M. Suzuki, K.-i. Yamamura, G. D. Armstrong, D. R. Bundle, In vivo supramolecular templating enhances the activity of multivalent ligands: A potential therapeutic against the Escherichia coli O157 AB5 toxins Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 16837- 16842 ,(2008) , 10.1073/PNAS.0804919105
Jiyun Liu, Zhongsheng Zhang, Xiaojian Tan, Wim G. J. Hol, Christophe L. M. J. Verlinde, Erkang Fan, Protein heterodimerization through ligand-bridged multivalent pre-organization: Enhancing ligand binding toward both protein targets Journal of the American Chemical Society. ,vol. 127, pp. 2044- 2045 ,(2005) , 10.1021/JA043817R
J. C. Chaput, C. Switzer, A DNA pentaplex incorporating nucleobase quintets. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 10614- 10619 ,(1999) , 10.1073/PNAS.96.19.10614
D. Calvin Harris, Xiaozhu Chu, Janarthanan Jayawickramarajah, DNA-Small Molecule Chimera with Responsive Protein-Binding Ability Journal of the American Chemical Society. ,vol. 130, pp. 14950- 14951 ,(2008) , 10.1021/JA806552C
Fen‐Hong QIAN, Qian Zhang, Lin‐Fu ZHOU, Hua Liu, Mao Huang, Xi‐Long ZHANG, Kai‐Sheng YIN, None, High‐sensitivity C‐reactive protein: A predicative marker in severe asthma Respirology. ,vol. 13, pp. 664- 669 ,(2008) , 10.1111/J.1440-1843.2008.01314.X
K. Ingrid Sprinz, Debarati M. Tagore, Andrew D. Hamilton, Self-assembly of bivalent protein-binding agents based on oligonucleotide-linked organic fragments Bioorganic & Medicinal Chemistry Letters. ,vol. 15, pp. 3908- 3911 ,(2005) , 10.1016/J.BMCL.2005.05.094
Debarati M. Tagore, K. Ingrid Sprinz, Steven Fletcher, Janarthanan Jayawickramarajah, Andrew D. Hamilton, Protein Recognition and Denaturation by Self‐Assembling Fragments on a DNA Quadruplex Scaffold Angewandte Chemie. ,vol. 46, pp. 223- 225 ,(2007) , 10.1002/ANIE.200603479
Mark B. Pepys, Gideon M. Hirschfield, Glenys A. Tennent, J. Ruth Gallimore, Melvyn C. Kahan, Vittorio Bellotti, Philip N. Hawkins, Rebecca M. Myers, Martin D. Smith, Alessandra Polara, Alexander J. A. Cobb, Steven V. Ley, J. Andrew Aquilina, Carol V. Robinson, Isam Sharif, Gillian A. Gray, Caroline A. Sabin, Michelle C. Jenvey, Simon E. Kolstoe, Darren Thompson, Stephen P. Wood, Targeting C-reactive protein for the treatment of cardiovascular disease Nature. ,vol. 440, pp. 1217- 1221 ,(2006) , 10.1038/NATURE04672