CD10 is a diagnostic and prognostic marker in renal malignancies.
作者： C Langner , M Ratschek , P Rehak , L Schips , R Zigeuner
DOI: 10.1111/J.1365-2559.2004.01982.X
关键词: Tissue microarray 、 Gastroenterology 、 Chromophobe cell 、 Transitional cell carcinoma 、 Urinary system 、 Univariate analysis 、 Internal medicine 、 Pathology 、 Anatomical pathology 、 Kidney disease 、 Renal cell carcinoma 、 Medicine
摘要: Aims: To determine the diagnostic and prognostic value of CD10 immunoreactivity in renal cell carcinomas (RCCs) transitional (TCCs). Methods results: expression was investigated primary (n = 180) metastatic (n = 58) RCCs upper urinary tract TCCs (n = 53) using a tissue microarray technique. One hundred fifty-four 172 (90%) evaluable 48/56 (86%) expressed CD10. Extensive (positivity >50% cancer cells) decreased with rising tumour grade conventional [G1/G2 72/81 (89%), G3/G4 33/48 (69%); P = 0.009]. Chromophobe showed significantly lower overall extensive compared tumours (P < 0.001). In papillary more than 10% cells for seen often type 2 (7/8, 88%) 1 (5/12, 42%; P =0.054) tumours. RCCs, pure apical membranous staining associated low stage (P = 0.003), (P = 0.004) improved prognosis on univariate analysis (P = 0.031). were less frequently stained (51%). staining, however, high-stage (P = 0.024), high-grade (P = 0.073) tumours, shorter disease-free survival (P = 0.003). Conclusions: proved to be an additional marker malignancies predominantly potential.
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