Multi-Objective Design of a Biodegradable Coronary Artery Stent

摘要: Ever since the mid 1980s when first-in-man coronary stent procedure was conducted, commercially available stents have evolved from original stainless steel Palmaz-Schatz style of design to a range highly flexible, slick structures capable providing arterial support with very thin struts. The availability modern alloys such as platinum-chromium has facilitated evolution strutted, flexible devices. However, an important juncture been reached wherein combination struts and low numbers links/bridges introduced new challenge associated loss longitudinal strength. Interestingly, this coincided increasing focus on use biodegradable materials (e.g., polymers or magnesium). So, whilst polymer scaffolds currently require relatively thick struts, it might be anticipated that efforts will made develop stronger also leading thinner but awareness pitfalls emphasis particular measures performance (objectives) at expense others. In parallel stents, computational methods (and hardware) developed point whereby optimization simulation tools can now used systematically devices in realistic time-scale. This chapter demonstrates how these harnessed guide multi-objective process, ultimate aim superior prototypes, particularly those are biodegradable, designed refined computationally.