Molecular interactions between glucocorticoids and β 2 -agonists
作者： Ian M. Adcock , D. A. Stevens
DOI: 10.1007/978-3-7091-7513-2_2
关键词: Stimulation 、 Molecular interactions 、 Cell biology 、 Myosin light-chain kinase 、 Transcription factor 、 CAMP response element binding 、 Inflammatory response 、 Biology 、 Glucocorticoid receptor 、 Cell
摘要: Glucocorticoids and β2-agonists may regulate gene transcription in a cell- gene-specific manner at both the transcriptional post-transcriptional level. For this factor interaction to be of importance asthma, it must occur cell or cells which are key targets for steroids also express surface β2-receptors respond β2-agonist stimulation with elevation cAMP. Many pulmonary these same GR. Airway epithelial cells, T-lymphocytes macrophages target an effect therapeutic relevance, particularly as all produce cytokines orchestrate perpetuate allergic inflammatory response.
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