Amidation via ligand-free direct oxidative C(sp3)-H/NH coupling with Cu-CPO-27 metal-organic framework as a recyclable heterogeneous catalyst

摘要: Abstract A copper-based metal-organic framework Cu-CPO-27 was synthesized, and used as a recyclable catalyst for the amidation of unactivated alkanes by benzamides via direct oxidative C(sp3)-H/N H coupling under ligand-free conditions. Using catalytic amount transformation, high yields N-cyclohexyl were achieved. The more catalytically active than other Cu-MOFs such Cu3(BTC)2, Cu(BDC), Cu(EDB), Cu2(BPDC)2(BPY), Cu2(BDC)2(DABCO), Cu2(EDB)2(BPY). also exhibited advantages compared to several salts, including Cu(OAc)2, CuCl2, CuBr, CuI, CuCl, Cu(NO3)2, CuSO4. could be reused times transformation while its activity not decreased significantly. To best our knowledge, previously performed heterogeneous catalysis