Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by insulin-like growth factor binding protein-3 (igfbp-3)
作者： Dae-Yeol Lee
DOI:
关键词: Immunology 、 Asthma 、 Insulin-like growth factor-binding protein 、 Airway hyperresponsiveness 、 Recombinant DNA 、 Respiratory system 、 Blockade 、 Inflammation 、 Medicine 、 Mutant
摘要: The physiological role of IGFBP-3 in respiratory inflammation and hyperresponsiveness is presently unknown. present invention based on the unexpected finding that both wild-type mutant GGG-IGFBP-3 inhibit tissue associated with obstructive disorders such as bronchial asthma. Provided herein are methods treating various conditions airway hyperresponsiveness, including asthma, by administering recombinant or mutants vectors encoding mutants.
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