Synthesis of benzimidazoles in high-temperature water

摘要: The objective of this research was to conduct constructive organic chemistry in water and achieve yields that were comparable to, or better than, those conventional media. synthesis 2-phenylbenzimidazole from 1,2-phenylenediamine benzoic acid chosen as a benchmark reaction. reaction parameters, such temperature, density time, have been systematically studied understand whether the solvent properties high-temperature can positive effect on chemistry. performed new design batch-type autoclave also monitored situ by UV-vis spectroscopy. By tuning yield has optimised around 90%. conditions then applied related benzimidazoles, some which crystallised solution single crystals sufficiently pure be analysed directly X-ray diffraction, without any further purification.