Exposures to molds in school classrooms of children with asthma

作者: Jonathan Gaffin , Perdita Permaul , Lianne S. Kopel , Peggy S. Lai , Jeffrey P. Lane

DOI: 10.1111/PAI.12127

关键词: MicrobiologyMoldAsthmatic childrenAspergillusToxicologySporeDirect microscopyMold sporesAsthmaBiologyCladosporium

摘要: Background Students spend a large portion of their day in classrooms which may be source mold exposure. We examined the diversity and concentrations molds inner-city schools described differences between within same school. Methods Classroom airborne spores, collected over 2 day period, were measured twice during school year by direct microscopy. Results There 180 classroom air samples from 12 schools. Mold was present 100% classrooms. Classrooms had differing levels scores. The total per 176.6 ± 4.2 spores/m3 (geometric mean ± standard deviation) ranged 11.2 to 16,288.5 spores/m3. scores for 1 19 (7.7 ± 3.5). accounted majority variance (62%) count, (56%) score versus school. species with highest found most commonly included Cladosporium (29.3 ± 4.2 spores/m3), Penicillium/Aspergillus (15.0 ± 5.4 smut spores (12.6 ± 4.0 basidiospores (6.6 ± 7.1 spores/m3). Conclusions Our study that is exposure, but particularly microenvironment varies quantity among also verified visible predictor higher spore counts. Further studies are needed determine clinical significance exposure relative asthma morbidity sensitized non-sensitized asthmatic children.

参考文章(33)
Lisa Vailes, Susheela Sridhara, Oliver Cromwell, Bernhard Weber, Michael Breitenbach, Martin Chapman, Quantitation of the major fungal allergens, Alt a 1 and Asp f 1, in commercial allergenic products Journal of Allergy and Clinical Immunology. ,vol. 107, pp. 641- 646 ,(2001) , 10.1067/MAI.2001.114118
Estelle Levetin, Richard Shaughnessy, Eugene Fisher, Bryan Ligman, Jed Harrison, Terry Brennan, Indoor air quality in schools: exposure to fungal allergens Aerobiologia. ,vol. 11, pp. 27- 34 ,(1995) , 10.1007/BF02136141
Maritta S. Jaakkola, Antonia Ieromnimon, Jouni J.K. Jaakkola, Are atopy and specific IgE to mites and molds important for adult asthma The Journal of Allergy and Clinical Immunology. ,vol. 117, pp. 642- 648 ,(2006) , 10.1016/J.JACI.2005.11.003
P TARGONSKI, V PERSKY, V RAMEKRISHNAN, Effect of environmental molds on risk of death from asthma during the pollen season The Journal of Allergy and Clinical Immunology. ,vol. 95, pp. 955- 961 ,(1995) , 10.1016/S0091-6749(95)70095-1
Matthew S. Perzanowski, Richard Sporik, Susan P. Squillace, Lawrence E. Gelber, Robert Call, Melody Carter, Thomas A.E. Platts-Mills, Association of sensitization to Alternaria allergens with asthma among school-age children The Journal of Allergy and Clinical Immunology. ,vol. 101, pp. 626- 632 ,(1998) , 10.1016/S0091-6749(98)70170-8
Marion Flamant-Hulin, Isabella Annesi-Maesano, Denis Caillaud, Relationships between molds and asthma suggesting non-allergic mechanisms. A rural-urban comparison. Pediatric Allergy and Immunology. ,vol. 24, pp. 345- 351 ,(2013) , 10.1111/PAI.12082
Yulia Y. Iossifova, Tiina Reponen, Patrick H. Ryan, Linda Levin, David I. Bernstein, James E. Lockey, Gurjit K. Khurana Hershey, Manuel Villareal, Grace LeMasters, Mold exposure during infancy as a predictor of potential asthma development Annals of Allergy, Asthma & Immunology. ,vol. 102, pp. 131- 137 ,(2009) , 10.1016/S1081-1206(10)60243-8
George T. O'Connor, Michelle Walter, Herman Mitchell, Meyer Kattan, Wayne J. Morgan, Rebecca S. Gruchalla, Jacqueline A. Pongracic, Ernestine Smartt, James W. Stout, Richard Evans III, Airborne fungi in the homes of children with asthma in low-income urban communities: The Inner-City Asthma Study. The Journal of Allergy and Clinical Immunology. ,vol. 114, pp. 599- 606 ,(2004) , 10.1016/J.JACI.2004.05.064
Tiina Reponen, Sung-Chul Seo, Faye Grimsley, Taekhee Lee, Carlos Crawford, Sergey A. Grinshpun, Fungal Fragments in Moldy Houses: A Field Study in Homes in New Orleans and Southern Ohio. Atmospheric Environment. ,vol. 41, pp. 8140- 8149 ,(2007) , 10.1016/J.ATMOSENV.2007.06.027
T Taskinen, A Hyvärinen, T Meklin, T Husman, A Nevalainen, M Korppi, Asthma and respiratory infections in school children with special reference to moisture and mold problems in the school Acta Paediatrica. ,vol. 88, pp. 1373- 1379 ,(2007) , 10.1111/J.1651-2227.1999.TB01054.X