Hemorrhagic complications of long-term anticoagulant therapy in 7 patients with systemic lupus erythematosus and antiphospholipid syndrome.

摘要: Objective To describe the presentation, course, and management of serious hemorrhagic complications anticoagulant therapy for patients with antiphospholipid syndrome (APS). Methods Charts identified bleeding from anticoagulation APS were reviewed. Results Patients included 6 women one man systemic lupus erythematosus (SLE) woman primary APS. One patient had 3 separate events. There episodes subdural hematoma in 5 patients, episode pericarditis tamponade, hemoptysis, ovarian hemorrhage. In 2 symptoms related to hemorrhage initially attributed active SLE. Duration was between month 10 years at time bleed. International normalized ratio (INR) prothrombin above intended range 6/9 episodes. no deaths permanent sequelae due bleeding. Anticoagulant resumed 6/7 patients. Conclusion The must include vigilance, education, maintain INR 3.5. prevent complications, low molecular weight heparin is an option that deserves further study.