Effects of DNA repair gene polymorphisms on DNA damage in human lymphocytes induced by a vinyl chloride metabolite in vitro.
作者： Nannan Feng , Yongliang Li , Changmin Long , Zhao-lin Xia , Paul W. Brandt-Rauf
DOI: 10.3109/1354750X.2014.907345
关键词: Genotype 、 Lymphoblast 、 DNA repair 、 Molecular biology 、 Micronucleus 、 Chloroacetaldehyde 、 Biology 、 XRCC1 、 Micronucleus test 、 DNA damage
摘要: AbstractBackground: Epidemiologic studies suggest that variability in DNA damage from vinyl chloride monomer (VCM) may be partially mediated by genetic polymorphisms repair. This study aimed to corroborate these observations with controlled experiments vitro using cell lines individuals differing repair genotypes determine following VCM metabolite exposure.Methods: Matched pairs of lymphoblast (homozygous wild-type versus homozygous variant for either XRCC1 399 or XPD 751 polymorphism) were exposed chloroacetaldehyde and analyzed the cytokinesis-block micronucleus assay.Results: All demonstrated a dose–response increasing micronuclei exposure, but both XPD, polymorphic cells peaked at higher frequencies declined slower rate baseline than cells.Conclusion: supports findings result deficient VCM-induced geneti...
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