Abnormal cerebral effective connectivity during explicit emotional processing in adults with autism spectrum disorder
作者： Bruno Wicker , Pierre Fonlupt , Bénédicte Hubert , Carole Tardif , Bruno Gepner
DOI: 10.1093/SCAN/NSN007
关键词: Psychology 、 Prefrontal cortex 、 Autism spectrum disorder 、 Facial expression 、 High-functioning autism 、 Asperger syndrome 、 Socioemotional selectivity theory 、 Autism 、 Cognitive psychology 、 Neuroscience 、 Social perception
摘要: Several recent studies suggest that autism may result from abnormal communication between brain regions. We directly assessed this hypothesis by testing the presence of abnormalities in a model functional cerebral network engaged during explicit emotion processing adults with high functioning or Asperger syndrome. Comparison structural equation models revealed patterns effective connectivity, prefrontal cortex as key site dysfunction. These findings provide evidence long-range connectivity structures ‘social brain’ could explain socioemotional troubles characterize autistic pathology.
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